Information om | Engelska ordet Β-LACTAM

Exempel på hur man kan använda Β-LACTAM i en mening

• The β-lactam ring is part of the core structure of several antibiotic families, the principal ones being the penicillins, cephalosporins, carbapenems, and monobactams, which are, therefore, also called β-lactam antibiotics.
• These antibiotics all have a common element in their molecular structure: a four-atom ring known as a beta-lactam (β-lactam) ring.
• Penicillins (P, PCN or PEN) are a group of β-lactam antibiotics originally obtained from Penicillium moulds, principally P.
• β-Lactam antibiotics (beta-lactam antibiotics) are antibiotics that contain a β-lactam ring in their chemical.
• Methicillin (USAN), also known as meticillin (INN), is a narrow-spectrum β-lactam antibiotic of the penicillin class.
• These include peptidoglycan synthesis inhibitors such as fosfomycin, vancomycin, moenomycin, lactivicin and the β-lactam antibiotics.
• A group including Dorothy Hodgkin publish the three-dimensional molecular structure of penicillin, demonstrating that it contains a β-lactam ring.
• β-lactam antibiotics, vancomycin, rifampicin, sulphonamides, ciprofloxacin, NSAIDs, ranitidine, cimetidine, furosemide, thiazides, phenytoin.
• Tazobactam is combined with the extended spectrum β-lactam antibiotic piperacillin in the drug piperacillin/tazobactam, used in infections due to Pseudomonas aeruginosa.
• For β-lactam antipseudomonal antibiotics, including piperacillin/tazobactam, prolonged intravenous infusion is associated with lower mortality than bolus intravenous infusion in persons with sepsis due to Pseudomonas aeruginosa.
• Ticarcillin, like penicillin, contains a β-lactam ring that can be cleaved by β-lactamases, resulting in inactivation of the antibiotic.
• As a β-lactam antibiotic in the third-generation class of cephalosporins, cefotaxime is active against numerous Gram-positive and Gram-negative bacteria, including several with resistance to classic β-lactams such as penicillin.
• Imipenem (trade name Primaxin among others) is a synthetic β-lactam antibiotic belonging to the carbapenems chemical class.
• Despite flucloxacillin being insensitive to beta-lactamases, some organisms have developed resistance to it and other narrow-spectrum β-lactam antibiotics including methicillin.
• They are bicyclic ring systems containing a β-lactam moiety fused with a five-member thiazolidine ring.
• Ampicillin/flucloxacillin (INNs) also known as co-fluampicil (BAN), and sold under the tradename Magnapen, is a combination drug of the two β-lactam antibiotics, ampicillin and flucloxacillin, both in equal amounts, available in a capsule and as a liquid, both taken by mouth, and as a formulation which can be given by injection into muscle or vein.
• All β-lactam antibiotics (except for tabtoxinine-β-lactam, which inhibits glutamine synthetase) bind to PBPs, which are essential for bacterial cell wall synthesis.
• After the war, he obtained an ICI fellowship (for 1946–1949) that allowed him to return to Imperial College to pursue independent research: an early highlight was his synthesises of penicillic acid, the major product of acid degradation of penicillin (although not containing its characteristic β-lactam substructure).
• β-lactamase, an enzyme that confers resistance to β-lactam antibiotics (and is encoded by the gene bla).
• Draining of the abscess and antibiotics: IV metronidazole and third generation cephalosporin/quinolones, β-lactam antibiotics, and aminoglycosides are effective.

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