Information om | Engelska ordet APALUTAMIDE

Exempel på hur man kan använda APALUTAMIDE i en mening

• Antiandrogens: apalutamide, bicalutamide, cimetidine, darolutamide, DIMP, enzalutamide, EPI-001, EPI-506, flutamide, hydroxyflutamide, inocoterone, inocoterone acetate, nilutamide, RU-58642, RU-58841, and topilutamide.
• Two 2020 meta-analyses reported that enzalutamide and apalutamide seemed to be more effective than darolutamide in improving metastasis-free survival (MFS), however 2021 matched adjusted indirect comparison showed no significant differences between drugs in terms of MFS.
• Similarly to the related second-generation NSAA enzalutamide but unlike first-generation NSAAs like flutamide and bicalutamide, elevated liver enzymes and hepatotoxicity have not been reported with apalutamide.
• Both darolutamide and ketodarolutamide show limited central nervous system distribution, indicating peripheral selectivity, and little or no inhibition or induction of cytochrome P450 enzymes such as CYP3A4, unlike enzalutamide and apalutamide.
• Enzalutamide and related second-generation NSAAs like RD-162 and apalutamide were derived from bicalutamide and as a result are similar to it in chemical structure.
• Compared to the second-generation NSAAs, enzalutamide and apalutamide, bicalutamide has inferior potency and efficacy but similar tolerability and safety and a lower propensity for drug interactions.
• Examples: cyproterone acetate, chlormadinone acetate, spironolactone, flutamide, bicalutamide, enzalutamide, apalutamide.
• Other structural analogues of rezvilutamide that are also used as antiandrogens besides enzalutamide include apalutamide and proxalutamide.

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