Information om | Engelska ordet AUTOREACTIVE

Exempel på hur man kan använda AUTOREACTIVE i en mening

• CCL21 is produced in the thymus medulla by medullary thymic epithelial cells, and it attracts single positive thymocytes from the thymus cortex to the medulla, where they undergo negative selection to delete autoreactive thymocytes.
• Thus, mTECs are capable to present self-generated TRAs on their MHC molecules to select potential autoreactive T cells.
• Two processes of central tolerance take place in thymic medulla, namely clonal deletion (recessive tolerance) and T Regulatory cells selection (dominant tolerance) which force autoreactive T cells to apoptosis or skew them into suppressor T regulatory cells (TRegs), respectively, in order to protect body against manifestations of autoimmunity.
• This approach expands a specific type of immune cells, called antigen-specific regulatory effector T cells, which suppress autoreactivity against the targeted autoantigens and also promote inhibition of autoreactive T cells against other myelin-specific autoantigens.
• Many group 1 CD1–restricted T cells are autoreactive, and autoreactivity is enhanced by stimulation through pattern recognition receptors (PRRs).
• mTECs (medullary thymic epithelial cells) in the medulla contribute to the development of T cell tolerance by purging autoreactive T lymphocytes by expression of cell-type-specific genes referred to as tissue-restricted antigens (TRA), and they also participate in the final stages of thymocyte maturation.

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