Information om | Engelska ordet CAPZ

Exempel på hur man kan använda CAPZ i en mening

• When CapZ is inhibited by regulating factors, microfilament polymerization or depolymerization occurs allowing lamellipodia and filopodia to grow out or retract.
• It has also been observed that CapZ functions to organize myofilaments during myofibrillogenesis and is present at Z-discs in muscle prior to the striation of actin filaments, suggesting that CapZ may function to direct the polarity and organization of sarcomeric actin during I-band formation.
• In muscle, the interaction of CapZ with actin is critical during myofibrilogenesis, as administration of a CapZ monoclonal antibody or expression of CapZ mutant protein disrupts actin filament formation and assembly of myofibrils.
• Indeed, paracingulin can interact with and thus recruit Tiam1 to the junction, allowing the local activation of Rac1 Both paracingulin depletion and overexpression experiments also led to the conclusion that it also interacts with and recruits SH3BP1, which is an inactivator of the Rho GTPases Cdc42 and Rac1 involved in epithelial junction formation in association with the filamentous actin-capping protein CapZ, by controlling actin-driven membrane remodeling.
• Involves the degradation of polyphosphoinositides and reactivation of "barbed end" capping proteins Hsp70 and CapZ, thereby reinitiating barbed-end capping and greatly diminishing elongation.

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