Synonymer & Anagram | Engelska ordet CD45

Exempel på hur man kan använda CD45 i en mening

• The cells must express CD73, CD90 and CD105 and they must be negative for CD14 or CD11b, CD34, CD45, CD79 alpha or CD19 and HLA-DR.
• The expression of several PTPS is restricted to hematopoietic cells, for example, LYP, SHP1, CD45, and HePTP.
• CD45 contains an extracellular domain, a single transmembrane segment, and two tandem intracytoplasmic catalytic domains, and thus belongs to the receptor type PTP family.
• Immunohistochemical panels for the diagnosis of Hodgkin's disease typically employ CD15 along with CD30 and CD45; the latter does not stain Reed–Sternberg cells, but does stain almost all other lymphoid cells.
• 'The differential regulation by CD45 of Lck kinase phosphorylation sites is critical for TCR signalling thresholds'.
• CD100 increases PMA, CD3 and CD2 induced T cell proliferation, increases CD45 induced T cell adhesion, induces B cell homotypic adhesion and down-regulates B cell expression of CD23.
• Traditional CTCs are characterised by an intact, viable nucleus; the expression of EpCAM and cytokeratins, which demonstrate epithelial origin; the absence of CD45, indicating the cell is not of hematopoietic origin; and their larger size, irregular shape or subcellular morphology.
• Reed-Sternberg and Hodgkin (RSH) cells are rarely seen, and immunohistochemistry shows a different pattern on the malignant cells; RSH cells typically express CD15 and CD30, whereas LP cells lack expression of these markers, but express B cell markers like CD20, CD22, and CD79a and also express the common leukocyte antigen CD45, which is uncommon on RSH cells.
• Marker analysis has also led to debate over the origin of the cell type; it coexpresses CD45, a leukocyte common antigen, and CD15, a monocyte common antigen.
• On plasma membrane of a T cell there is the T-cell receptor (consists of α,β chains and multiple CD3 adaptor proteins), as well as molecules that induce signalling (tyrosine kinase Lck phosphorylates ITAMs in CD3 complex) and factors that inhibit signalling (tyrosine phosphatases CD45 and CD148).
• When immunophenotyped by flow cytometry, the cells are generally CD45 negative and may express CD56, a profile that is non-specific but unusual for hematologic malignancies.
• A recent immunohistochemical immunostaining small study on AMSF tumor tissue detected cells that expressed the vimentin protein in almost all cases; expressed MUC1 (also termed EMA), CD31, CD34, CD68, and PDPN proteins in a variable number of cases; and did not express CD45, CD15, CD30, HMB-45, MLANA (also termed Melan-A), desmin, GFAP, or S100 proteins.

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