Information om | Engelska ordet CENTROSOMAL

Exempel på hur man kan använda CENTROSOMAL i en mening

• Mutations in patients with Seckel syndrome have recently been identified in the gene encoding centrosomal protein CEP152 which is also mutated in some cases of primary isolated microcephaly.
• Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes.
• Ninein, together with its paralog Ninein-like protein is one of the proteins important for centrosomal function.
• It is an integral component of the PCM, which is a centrosome scaffold that anchors microtubule nucleating complexes and other centrosomal proteins.
• It has at least two distinct roles in spindle formation: it protects kinetochore microtubules from depolymerization by MCAK (KIF2C), and ch-Tog plays an essential role in centrosomal microtubule assembly, a function independent of MCAK activity.
• Due to these functions AKNA plays in the centrosomal microtubules it also has an active role in delamination during the formation of the subventricular zone, and the regulation of the amount of access provided to cells in this zone.
• KIAA1143 is experimentally determined to have interactions with EAPP (E2F-associated phosphoprotein), ECD (Ecdysoneless Cell Cycle Regulator), GPATCH1 (Evolutionarily Conserved G-Patch Domain-Containing Protein), PRPF8 (Pre-MRNA-Processing-Splicing Factor 8), WDR83 (Mitogen-Activated Protein Kinase Organizer 1), CEP76 (centrosomal protein 76), and APP (Amyloid-beta precursor protein).

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