Information om | Engelska ordet CONFORMATIONAL

Exempel på hur man kan använda CONFORMATIONAL i en mening

• Denatured proteins can exhibit a wide range of characteristics, from conformational change and loss of solubility or dissociation of cofactors to aggregation due to the exposure of hydrophobic groups.
• The energy from the redox reaction results in conformational change allowing hydrogen ions to pass through four transmembrane helix channels.
• In the fields of biochemistry and pharmacology an allosteric regulator (or allosteric modulator) is a substance that binds to a site on an enzyme or receptor distinct from the active site, resulting in a conformational change that alters the protein's activity, either enhancing or inhibiting its function.
• In molecular biology, molecular chaperones are proteins that assist the conformational folding or unfolding of large proteins or macromolecular protein complexes.
• It is solely a relationship of chirality and the permanent three-dimensional relationships among molecules or other chemical structures: no amount of re-orientiation of a molecule as a whole or conformational change converts one chemical into its enantiomer.
• In the 1960s through the 1970s, Paul Boyer, a UCLA Professor, developed the binding change, or flip-flop, mechanism theory, which postulated that ATP synthesis is dependent on a conformational change in ATP synthase generated by rotation of the gamma subunit.
• Conformation activity relationship between the biological activity and the conformation or conformational changes of a biomolecule.
• When an extracellular signal triggers the activation of a G-protein coupled receptor (GPCR), the associated G-protein exchanges its bound GDP for GTP, leading to a conformational change and activation of downstream signaling cascades.
• Light leads to conformational changes in rhodopsin, which in turn leads to the activation of transducin.
• Application of femtochemistry in biological studies has also helped to elucidate the conformational dynamics of stem-loop RNA structures.
• The epitopes of protein antigens are divided into two categories, conformational epitopes and linear epitopes, based on their structure and interaction with the paratope.
• As an iron-sulfur protein approaches the b-c1 complex, it accepts an electron from the cytochrome b subunit, then undergoes a conformational change to attach to cytochrome c1.
• This phosphorylation typically occurs on a specific threonine residue, leading to a conformational change in the CDK that enhances its kinase activity.
• There are 3 major domains on the cytoplasmic face of SERCA: the phosphorylation and nucleotide-binding domains, which form the catalytic site, and the actuator domain, which is involved in the transmission of major conformational changes.
• The types of biological activity that have been investigated using molecular modelling include protein folding, enzyme catalysis, protein stability, conformational changes associated with biomolecular function, and molecular recognition of proteins, DNA, and membrane complexes.
• It is concluded that conformational disorder is a constitutive feature of elastin structure and function.
• Moreover, SAXS/SANS also made possible real time investigations of intermolecular interactions, including assembly and large-scale conformational changes in macromolecular assemblies.
• In the retina, this conversion induces a conformational change in the surrounding opsin protein pigment, leading to signaling through the G protein transducin.
• AAA proteins couple chemical energy provided by ATP hydrolysis to conformational changes which are transduced into mechanical force exerted on a macromolecular substrate.
• These adjustments can lead to the nucleation of particles of varying sizes by polymorphic or amorphous transformations, as well as due to the characteristics of aggregation processes, which in some cases is accompanied by changes in conformational equilibria.

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