Information om | Engelska ordet CONNEXINS

Exempel på hur man kan använda CONNEXINS i en mening

• In biology, a connexon, also known as a connexin hemichannel, is an assembly of six proteins called connexins that form the pore for a gap junction between the cytoplasm of two adjacent cells.
• Each gap junction is composed of two hemichannels, or connexons, which consist of homo- or heterohexameric arrays of connexins, and the connexon in one plasma membrane docks end-to-end with a connexon in the membrane of a closely opposed cell.
• Modafinil may promote wakefulness by modulating the function of astroglial connexins, specifically connexin 30, which are proteins that facilitate intercellular communication and play a role in sleep-wake regulation.
• Mutations in distinct genes, which encode the main cytoplasmic proteins of human lens, have been associated with cataracts of various morphologies, including genes encoding crystallins (CRYA, CRYB, and CRYG), lens specific connexins (Cx43, Cx46, and Cx50), major intrinsic protein (MIP) or Aquaporin, cytoskeletal structural proteins, paired-like homeodomain transcription factor 3 (PITX3), avian musculoaponeurotic fibrosarcoma (MAF), and heat shock transcription factor 4 (HSF4).
• She has studied the role of keratin in non-melanoma skin cancers and hereditary skin diseases, and discovered that numerous genetic diseases of the skin are caused by mutations in keratin, plectin, desmosomal proteins and connexins.
• Voltage gating modulation is associated with the charge of connexin; positively charged connexin close with hyperpolarization and negatively charged connexins close with depolarization.
• Pannexins, connexins, and innexins are transmembrane proteins that are all named after the Latin term nexus, meaning to connect.
• These junctions are made up of a number of gap junction channels that consist of two connexons, each with six protein subunits called connexin, and a gene family of nearly 20 members encodes the connexins found in mammals.

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