Anagram & Information om | Engelska ordet CTCF

Exempel på hur man kan använda CTCF i en mening

• The protein CTCF is involved in repressing expression of the gene, by binding to the H19 imprinting control region (ICR) along with Differentially-methylated Region-1 (DMR1) and Matrix Attachment Region −3 (MAR3).
• CTCF protein is known to favourably bind to unmethylated sites, so it follows that methylation of CpG islands is a point of epigenetic regulation.
• The protein CTCF plays a heavy role in repressing the insulin-like growth factor 2 gene, by binding to the H-19 imprinting control region (ICR) along with differentially-methylated region-1 (DMR1) and MAR3.
• Transcriptional repressor CTCFL (this protein) is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells.
• Additionally, the chromatin organization factors CTCF (CCCTC-Binding Factor), Cohesin, and Rad21 - which are known to aid in the recruitment of RNAPII - have also been shown to bind within 1-2 kilobases of the telomeric tracks just upstream of these CpG islands.
• PROSER2 interacts most strongly with the following transcription factors: Vertebrate TATA binding protein factor, ZF5 POZ domain zinc finger, CTCF and BORIS gene family transcriptional regulators, E2F-myc activator/cell cycle regulator, MYT1 C2HC zinc finger protein, SOX/SRY– sex/testis determining and related HMG box factors, CCAAT binding factors, HOX-PBX complexes, and C2HC zinc finger transcription factors 13.
• However, the handcuff model and the loop extrusion model describe the TAD formation by the aid of CTCF and cohesin proteins.
• The process is facilitated by a number of factors including architectural proteins (primarily CTCF and Cohesin), transcription factors, co-activators, and ncRNAs.
• TIGs per definition are single protein coding genes (PCGs) within CTCF loop domains, that are mainly enriched in developmental regulators and suggested to be very tightly controlled via their 3D loop-domain architecture.

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