Information om | Engelska ordet CYCLOSPORIN

Exempel på hur man kan använda CYCLOSPORIN i en mening

• Ciclosporin, also spelled cyclosporine and cyclosporin, is a calcineurin inhibitor, used as an immunosuppressant medication.
• Cyclophilins (CYPs) are a family of proteins named after their ability to bind to ciclosporin (cyclosporin A), an immunosuppressant which is usually used to suppress rejection after internal organ transplants.
• More severe AD cases may need systemic medicines such as cyclosporin, methotrexate, dupilumab or baricitinib.
• Evaluation of novel immune-based therapies using interferons, GM-CSF, G-CSF, thalidomide, IL-2, IL-12, cyclosporin (CsA), prednisone, cytotoxic agents, therapeutic immunization.
• This can be through a connection between the amino and carboxyl ends of the peptide, for example in cyclosporin; a connection between the amino end and a side chain, for example in bacitracin; the carboxyl end and a side chain, for example in colistin; or two side chains or more complicated arrangements, for example in alpha-amanitin.
• Also known as N-methyl-4-isoleucine cyclosporin, it is a substituted cyclosporine analog that binds to cyclophilin; however, this binary complex cannot bind to calcineurin, and therefore lacks immunosuppressive activity.
• This entry mechanism is inhibited by myrcludex B, cyclosporin A, progesterone, propranolol, bosentan, ezetimibe, bexarotene as well as NTCP substrates like taurocholate, tauroursodeoxycholate and bromosulfophthalein.
• When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin.
• There have also been reports of drug-induced tufted hair folliculitis associated with the use of cyclosporin, trastuzumab, and lapatinib.
• The available pharmacological treatments for MAGIC syndrome include biologics (tocilizumab and infliximab), immunosuppressants (cyclosporin A, methotrexate, cyclophosphamide, and azathioprine), steroids (corticosteroids, methylprednisolone, prednisolone, and prednisone), colchicines, dapsone, and nonsteroidal anti-inflammatory drugs.
• Caves was influential in the careers of future pioneering surgeons including John Wallwork, who joined Papworth Hospital's Heart transplant programme in 1981 and was experienced in the use of cyclosporin after heart transplant whilst a chief resident at Stanford, under Shumway.

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