Information om | Engelska ordet DALCETRAPIB

Exempel på hur man kan använda DALCETRAPIB i en mening

• These drugs have generally failed in clinical trials, either causing a marked increase in deaths (torcetrapib), or having no meaningful clinical improvement despite HDL increases (dalcetrapib, evacetrapib).
• However, the results of the dal-GenE trial showed a 21% relative risk reduction (RRR) in fatal and non-fatal MI in 6,149 patients across 34 countries, and a 45% RRR for the same endpoint in 1,200 patients in North America and further confirmed the safety profile of dalcetrapib.
• Evacetrapib evaluation for treatment of high-risk vascular disease was discontinued due to lack of efficacy, as had already happened in the past with two other CETP inhibitors (torcetrapib and dalcetrapib) due to increased deaths and little identifiable cardiovascular benefit (despite substantial increases in HDL).
• This pharmacogenomic study of approximately 6000 patients with coronary artery disease suggested that the effects of the CETP inhibitor dalcetrapib on both cardiovascular outcomes and atherosclerosis imaging are determined by polymorphisms in the ADCY9 gene.

Förberedelsen av sidan tog: 131,79 ms.