Information om | Engelska ordet DEAMIDATION

Exempel på hur man kan använda DEAMIDATION i en mening

• Although deamidation occurs on glutamine, glycosylated asparagine and other amides, these are negligible under typical proteolysis conditions.
• Aside from its crosslinking function, tTG catalyzes other types of reactions including deamidation, GTP-binding/hydrolyzing, and isopeptidase activities.
• Omega amidase catalyzes the deamidation of several different alpha-keto acids into ammonia and metabolically useful carboxylic acids The general mechanism is the same as for other nitrilases: binding of the substrate to the active site, followed by release of ammonia, formation of a thioester intermediate at the cysteine, binding of water and then release of the carboxylic acid product.
• In terms of post-translational modifications (changes occur after RNA translation), ancient proteins are often characterised by extensive damage such as oxidation (methionine), hydroxylation (proline), deamidation (glutamine/asparagine), citrullination (arginine), phosphorylation (serine/threonine/tyrosine), N-terminus glutamate to pyroglutamate and the addition of advanced glycation products to lysine or arginine.
• Chemical modification takes place on connexin proteins after their translation and typically involves changes in phosphorylation and ubiquitination, although nitrosylation, deamidation and hydroxylation have also been noted to be modifying processes.
• An answer to this conundrum came with the observation that transglutaminase 2, an enzyme to which celiac disease patients generate autoantibodies, can posttranslationally modify gluten peptides by converting certain glutamine residues to negatively charged glutamate residues in a process called deamidation.

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