Information om | Engelska ordet ENKEPHALINS

Exempel på hur man kan använda ENKEPHALINS i en mening

• Gate control theory led to the valuable discovery of endorphins and enkephalins, the body's natural opiates.
• The signalling within the chemoreceptors is thought to be mediated by the release of neurotransmitters by the glomus cells, including dopamine, noradrenaline, acetylcholine, substance P, vasoactive intestinal peptide and enkephalins.
• β-endorphin and other enkephalins are often released with ACTH to modulate hormone system functioning.
• Snyder and his assistant, Candace Pert, made the critical discovery that the receptors for opiates were in each brain cell, and the search began for opiate substances within the body, later called enkephalins.
• Neprilysin is a zinc-dependent metalloprotease that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.
• Since the discovery of the neuropeptides and peptide hormones from the central nervous system (ACTH, β-MSH, endorphin, oxytocin, vasopressin, LHRH, enkephalins, substance P), and of peripheral vasoactive peptides (angiotensin, bradykinin) around the middle of last century, the number of known biologically active peptides has exponentially increased.
• A combination of behavioral, pharmacological, and biochemical research led Akil and colleagues of the Barchas Laboratory at Stanford to the endorphins, specifically two peptides called enkephalins.
• Kelatorphan is a drug which acts as a powerful and complete inhibitor of nearly all of the enzymes responsible for catabolism of the endogenous enkephalins, including neutral endopeptidase (NEP), dipeptidyl peptidase III (DPP3), aminopeptidase N (APN), and angiotensin-converting enzyme (ACE).
• In the field of neuropeptides, Jean-Charles Schwartz created the concept of "inactivation neuropeptidases" by identifying the enzymes responsible for the metabolic inactivation of enkephalins and cholecystokininin and developed the first selective inhibitors of these enzymes, the latters used as research tools and then, from one of them thas therapeutic agent.
• ACKR3 is a novel opioid receptor which functions as a broad-spectrum trap or scavenger for endogenous opioid peptides, including enkephalins, dynorphins, and nociceptin.

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