Definition, Betydelse & Anagram | Engelska ordet GPCR

Definition av GPCR

1. (cellbiologi) förkortning för G protein–coupled receptor (G-proteinkopplad receptor)

Exempel på hur man kan använda GPCR i en mening

• Rhodopsin, also known as visual purple, is a protein encoded by the RHO gene and a G-protein-coupled receptor (GPCR).
• When an extracellular signal triggers the activation of a G-protein coupled receptor (GPCR), the associated G-protein exchanges its bound GDP for GTP, leading to a conformational change and activation of downstream signaling cascades.
• Studies within the chemokine receptor system also suggest that GPCR biased agonism is physiologically relevant.
• The D2sh autoreceptor has been shown recently to interact with the trace amine-assorted receptor 1 (TAAR1), a G-Coupled Protein Receptor GPCR, to regulate monoaminergic systems in the brain.
• The gonadotropin-releasing hormone receptor (GnRHR), also known as the luteinizing hormone releasing hormone receptor (LHRHR), is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family.
• It was out of this momentary radicalization of GPCR mass politics and its sudden suppression and redirection that the ultra-left currents were born under the direct order from Zhou Enlai, first independently within rebel groups scattered throughout China, then by late 1967 in increasing dialogue until their suppression during the following years.
• AVPR1A is a G-protein coupled receptor (GPCR) with 7 transmembrane domains that couples to Gaq/11 guanosine triphosphate (GTP) binding proteins, which along with Gbl, activate phospholipase C activity.
• These systems typically utilize G protein-coupled receptors (GPCR) engineered to respond exclusively to synthetic ligands, like clozapine N-oxide (CNO), and not to endogenous ligands.
• GPCR oligomers are discrete entities and usually possess properties distinct from their parent monomeric receptors.
• The protein that carries the Hh signal across the membrane is the oncoprotein and G-protein coupled receptor (GPCR) Smoothened (Smo).
• Endocannabinoids, synthesized in and released from postsynaptic neuronal elements and their cognate receptors, including the (GPCR) CB1 receptor located at the presynaptic terminal, are involved in this modulation by a retrograde signaling process, in which these compounds are synthesized in and released from postsynaptic neuronal elements and travel back to the presynaptic terminal to act on the CB1 receptor for short-term or long-term synaptic depression, that causes a short or long lasting decrease in neurotransmitter release.
• For example, GRK1 is regulated by the calcium sensor protein recoverin: calcium-bound recoverin binds directly to GRK1 to inhibit its ability to phosphorylate and desensitize rhodopsin, the visual GPCR in the retina, in light-activated retinal rod cells since light activation raises intracellular calcium in these cells, whereas in dark-adapted eyes, calcium levels are low in rod cells and GRK1 is not inhibited by recoverin.
• The receptor interacts with both luteinizing hormone (LH) and chorionic gonadotropins (such as hCG in humans) and represents a G protein-coupled receptor (GPCR).
• Interleukin-8 receptor, RANTES receptors (CCR1, CCR3, CCR5), MIP-1 receptor, PF4 receptor, M-CSF receptor and NAP-2 receptor belong to GPCR chemokine receptor family.
• Extracellular hormones, such as glucagon, epinephrine, thyroid-stimulating hormone, or adrenocorticotropic hormone (ACTH), bind to their respective G protein–coupled receptors (GPCR).
• When ligands bind a GPCR, the GPCR acquires GEF (guanine nucleotide exchange factor) ability, which activates the G-protein by exchanging the GDP on the alpha subunit to GTP.
• The urotensin-2 receptor (UR-II-R) also known as GPR14 is a class A rhodopsin family G protein coupled-receptor (GPCR) that is 386 amino acids long which binds primarily to the neuropeptide urotensin II.
• However, research has demonstrated that a number of GPCRs are also capable of forming heteromers from a combination of two or more individual GPCR subunits under some circumstances, especially where several different GPCRs are densely expressed in the same neuron.
• However, the activity of the human G2A receptor and its mouse homolog are significantly less sensitive to pH fluctuations than other pH sensing GPCRs; indeed, in studies of thymocytes and splenocytes taken from mice deficient in either the G2A or another pH-sensing GPCR, TDAG8, TDAG8 was found critical while G2A was found dispensable for sensing pH changes.
• Specifically, stimulation of a GPCR receptor, coupled to Gαq, results in the activation of phospholipase C β2 (PLC), which then stimulates the second messengers 1,4,5-inositol trisphosphate (IP3) and diacylglycerol (DAG).

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