Synonymer & Anagram | Engelska ordet HYPERALGESIA

Exempel på hur man kan använda HYPERALGESIA i en mening

• Also, the threshold of HT channels was lowered in the presence of PGE2 (a compound that sensitizes neurons to mechanical stimuli and mechanical hyperalgesia) which further supports a role for HT channels in the transduction of mechanical stimuli into nociceptive neuronal signals.
• In the context of pain, hyperaesthesia can refer to an increase in sensitivity where there is both allodynia and hyperalgesia.
• In opioid-induced hyperalgesia, sensitization of pronociceptive mechanisms occurs, resulting in a decrease in the pain threshold, or allodynia.
• Long-term complications can include bowel obstruction, failure to thrive, neurogenic bladder and paralysis, recurrent cardiorespiratory distress and pneumothorax, hypoxic brain injury leading to early dementia, amputations, chronic pain and pain with light touch (hyperalgesia), deep venous thrombosis with pulmonary embolus, limb swelling and debility, and lead poisoning.
• This ended up reducing the menthol-induced sensation of cold and hyperalgesia because blocking A fiber conduction resulted in inhibition of a class of group C nerve fiber nociceptors needed to transduce the sensation of pain.
• Palpate: over mid supraspinatus and roll the skin over the trapezius to test for signs of hyperalgesia or fibromyalgia.
• It is several hundred times selective for the ORL-1 receptor over other opioid receptors, and its effects in animals include preventing the development of tolerance to morphine, the prevention of hyperalgesia induced by intracerebroventricular administration of nociceptin (orphanin FQ), as well as the stimulation of dopamine release in the striatum, which increases the rewarding effects of cocaine, but may have clinical application in the treatment of Parkinson's disease.
• States of neuropathic pain, such as hyperalgesia and allodynia, are also directly related to mechanosensation.
• Moreover, high doses of morphine, and thus M3G, are associated with neurotoxic side effects such as hyperalgesia, allodynia and myoclonus.
• In addition, lidocaine microinjections into the RVM temporarily reversed allodynia and hyperalgesia caused by nerve injury.
• Patients may experience numbness, tingling, altered touch sensation, gait and balance disturbances, burning pain, thermal allodynia or hyperalgesia, impaired vibration sense, extreme temperature sensitivity, paresthesia, and/or dysesthesia as part of sensory damage.
• NAGly is also effective in acute pain models, reducing mechanical allodynia and thermal hyperalgesia induced by intraplantar injection of Fruend's complete adjuvant.
• Intraplantarly injection of PiTX-Kα before or after the administration of diclofenac produces a significant reduction in spontaneous flinching, mechanical allodynia and thermal hyperalgesia in a rat model for bone cancer.
• Almost always, a small area of maximal pain is covered by a larger area of altered skin sensibility with somatosensory disturbances such as hypoesthesia as well as hyperesthesia or hyperalgesia and change of cool perception.
• Interestingly, mice deficient of TNF receptor 1 develop mechanical allodynia after CCI (Chronic Constrictive Injury) but not thermal hyperalgesia, indicating a greater influence of endogenous TNF on thermal than on mechanical thresholds”.
• In 1996, they demonstrated  that the newly discovered orphan opioid peptide, orphanin FQ/nociception, did not produce hyperalgesia as originally reported, but rather was reversing the stress-induced analgesia resulting from the intracerebroventricular injection through which it was administered.
• Intrathecal injection of a HDAC inhibitory can reverse the CCI-induced hyperalgesia and mechanical allodynia.
• The therapeutic properties of neurotrophins attracted the focus of many researchers during the years, but the poor pharmacokinetic properties, such as reduced bioavailability and low metabolic stability, the hyperalgesia, the inability to penetrate the blood–brain barrier and the short half-lives render the large neurotrophin proteins not suitable to be implemented as drugs.

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