Information om | Engelska ordet INTRASTRAND

Exempel på hur man kan använda INTRASTRAND i en mening

• This crosslink can occur within the same strand (intrastrand) or between opposite strands of double-stranded DNA (interstrand).
• Electrophilic alkylating agents such as nitrogen mustards, methanesulfonates, and cisplatins tend to act in this manner to produce a variety of DNA damage products such as mono- and dialkylation, inter- and intrastrand crosslinks, and DNA-protein crosslinks.
• Important results include the identification of an intrastrand d(pGpG) cross-link as the major adduct on platinated single-stranded DNA, identification of the major adduct on double-stranded DNA, the binding of high-mobility-group proteins to platinated DNA cross-links.
• As studied mainly on cisplatin, but presumably for other members as well, platinum-based antineoplastic agents cause crosslinking of DNA as monoadduct, interstrand crosslinks, intrastrand crosslinks or DNA protein crosslinks.
• Cisplatin acts by binding to DNA, forming one or two intrastrand cross-links of the G-G adduct at 70% and the A-G adduct at ~20% of the major grooves of the double helix.

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