Anagram & Information om | Engelska ordet MESTRANOL

Mestranol is a biologically inactive prodrug of ethinylestradiol to which it is demethylated in the liver (via O-Dealkylation) with a conversion efficiency of 70% (50 μg of mestranol is pharmacokinetically bioequivalent to 35 μg of ethinylestradiol).
In 1952 Colton synthesized the progestin noretynodrel (an isomer of norethisterone), which combined with the estrogen mestranol as Enovid was approved by the U.
Mestranol/norethynodrel was the first combined oral contraceptive pill (COCP) being mestranol and norethynodrel.
Quingestrone was formerly used in combination with ethinylestradiol or mestranol in combined birth control pills in Italy.
In combination with mestranol, similarly to ethynerone and anagestone acetate (and certain other progestogens, including progesterone and several other 17α-hydroxyprogesterone derivatives), chloroethynylnorgestrel was found to produce striking mammary tumors in beagle dogs after administration at very high dosages (10- to 25-fold human clinical dosages) for prolonged periods of time.
Synthetic estrogens, such as 17α-substituted estrogens like ethinylestradiol and its C3 esters and ethers mestranol, quinestrol, and ethinylestradiol sulfonate, and nonsteroidal estrogens like the stilbestrols diethylstilbestrol, hexestrol, and dienestrol, are no longer used in menopausal hormone therapy, owing to their disproportionate effects on liver protein synthesis and associated health risks.

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