Synonymer & Information om | Engelska ordet MONOCYTE

Exempel på hur man kan använda MONOCYTE i en mening

• The proportion of immature leukocytes increases due to proliferation and inhibition of granulocyte and monocyte precursors in the bone marrow which is stimulated by several products of inflammation including C3a and G-CSF.
• These OMVs stimulate the expression of proinflammatory cytokine and chemokine genes, including interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor-α and monocyte chemoattractant protein-1.
• An increase in shear stress causes an increase in the number of monocyte chemoattractant protein-1 (MCP-1) molecules expressed on the surface of vessel walls as well as increased levels of TNF-α, bFGF, and MMP.
• The chemokine (C-C motif) ligand 2 (CCL2) is also referred to as monocyte chemoattractant protein 1 (MCP1) and small inducible cytokine A2.
• Shear stress leads to the activation and expression of all nitric oxide synthetase (NOS) isoforms and nitric oxide production, followed by vascular endothelial growth factor (VEGF) secretion, which induces monocyte chemoattractant protein-1 (MCP-1) synthesis in the endothelium and in the smooth muscle of the media.
• Certain melanoma cells can use VCAM-1 to adhere to the endothelium, VCAM-1 may participate in monocyte recruitment to atherosclerotic sites, and it is highly overexpressed in the inflamed brain.
• Extracellular ATP is a mediator of arterial wall hyperplasia and hypertrophy in this model, as notably demonstrated by Jacobson et al 2006 and Kolosova et al 2005 - a regulator of vascular permeability, by the same - and controls smooth muscle cell and blood cell (including monocyte) migration and proliferation, demonstrated in Gerasimovskaya et al 2002, Satterwhite et al 1999, Kaczmarek et al 2005, Lemoli et al 2004, and Rossi et al 2007.
• This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1 (CCL2), a chemokine which specifically mediates monocyte chemotaxis.
• The family members stimulate another blood cell of the innate immunity system, the human monocyte, acting synergistically with the pro-inflammatory CC chemokines, monocyte chemotactic protein-1 and monocyte chemotactic protein-3, to stimulate monocyte function.
• The protein encoded by this gene is an azurophil granule antimicrobial protein, with monocyte chemotactic and antibacterial activity.
• It addition, it has a role in cardiolipin (CL) deacylation, and is required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F-actin polymerization at the pseudopods.
• In other investigations, the team has identified novel lymphocyte, dendritic cell and macrophage chemoattractants and receptors, as well as monocyte and arterial wall endothelial molecules that regulate monocyte-endothelial interactions in models of atherogenesis.
• Marker analysis has also led to debate over the origin of the cell type; it coexpresses CD45, a leukocyte common antigen, and CD15, a monocyte common antigen.
• GM-CSF is produced by CAR-T cells upon recognition of target cells, which activates myeloid cells and compels them to produce monocyte chemoattractant protein 1 (MCP-1) and its receptor (CCR2).
• After a 2003 PhD titled T lymphocyte cyclooxygenase isotypes and the role of T lymphocytes in modulating monocyte and synoviocyte cyclooxygenase expression at the University of Adelaide, Stamp moved to the University of Otago, rising to full professor.
• Extremely high monocyte counts, as well as immature forms of monocytes, occur in chronic myelomonocytic leukemia and acute leukemias of monocytic origin.
• Similarly, Candida albicans and fungal β-glucan trigger changes in monocyte histone methylation, this functional reprogramming eventually provides protection against reinfection.
• The receptor on the monocyte or other phagocyte for ATP and UTP signals has been shown to be P2Y2 in vivo.
• Subsequently, his research identified several novel synovial cytokine amplificatory pathways involved in disease chronicity, such as PAR2 dependent matrix enzyme sensing, and autoantibody to MICL mediated monocyte activation.
• Although monocytes develop predominantly in bone marrow, Swirski showed that hypercholesterolemia leads to monocyte production in the spleen in a process called extramedullary hematopoiesis, which further drives atherosclerosis progression.

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