Information om | Engelska ordet MUTAGENICITY

Exempel på hur man kan använda MUTAGENICITY i en mening

• While genotoxicity is often confused with mutagenicity, all mutagens are genotoxic, but some genotoxic substances are not mutagenic.
• When 4NQO is metabolized to its electrophilic reactant, selyl-4HAQO, it reacts with DNA to form stable quinolone monoadducts considered responsible for its mutagenicity and genotoxicity.
• For mixtures, the label should include the chemical identities of all ingredients that contribute to acute toxicity, skin corrosion or serious eye damage, germ cell mutagenicity, carcinogenicity, reproductive toxicity, skin or respiratory sensitization, or Specific Target Organ Toxicity (STOT), when these hazards appear on the label.
• Comparative pharmacokinetics/metabolism, carcinogenicity and mutagenicity of chlorinated ethanes and ethylenes (meeting abstract).
• Positive results from mutagenicity analysis via the Ames test of compounds commonly found in preparations labelled "pangamic acid" including diisopropylamine dichloroacetate, diisopropylamine, dichloroacetate, as well as dimethylglycine mixed with sodium nitrite suggests there may be concern for the development of cancer with the use of these substances.
• Classification and labelling is harmonised to ensure an adequate risk management for hazards of highest concern (carcinogenicity, mutagenicity, reproductive toxicity (CMR) and respiratory sensitisers) and for other substances on a case-by-case basis.
• Toxicological studies have shown that some Cl-PAHs possess greater mutagenicity, aryl-hydorcarbon receptor activity, and dioxin-like toxicity than the corresponding parent PAHs.
• As with other bacterial genotoxicity and mutagenicity assays, compounds requiring metabolic activation for activity can be investigated with the addition of S9 microsomal rat liver extract.

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