Synonymer & Anagram | Engelska ordet OLIGODENDROCYTE

Exempel på hur man kan använda OLIGODENDROCYTE i en mening

• The myelin sheaths of oligodendrocytes do not have neurilemma because excess cytoplasm is directed centrally toward the oligodendrocyte cell body.
• These proteins have been shown to have diverse functions in the development of the nervous system and play multiple essential roles in vertebrate embryogenesis including: cardiac development, Schwann cell and oligodendrocyte differentiation, some aspects of neuronal development, as well as the formation of neuromuscular synapses.
• Oligodendrocyte progenitor cells (OPCs), also known as oligodendrocyte precursor cells, NG2-glia, O2A cells, or polydendrocytes, are a subtype of glia in the central nervous system named for their essential role as precursors to oligodendrocytes and myelin.
• Klotho is required for oligodendrocyte maturation, myelin integrity, and can protect neurons from toxic effects.
• Myelin oligodendrocyte glycoprotein (MOG) is a glycoprotein believed to be important in the myelination of nerves in the central nervous system (CNS).
• Remyelination is the process of propagating oligodendrocyte precursor cells to form oligodendrocytes to create new myelin sheaths on demyelinated axons in the Central nervous system (CNS).
• Myelin-associated glycoprotein (MAG, Siglec-4) is a type 1 transmembrane protein glycoprotein localized in periaxonal Schwann cell and oligodendrocyte membranes, where it plays a role in glial-axonal interactions.
• As the Redlich–Obersteiner's zone separates the CNS and PNS, there is a transition from Schwann cell myelin to oligodendrocyte myelin.
• The hostile, non-permissive growth environment is, in part, created by the migration of myelin-associated inhibitors, astrocytes, oligodendrocytes, oligodendrocyte precursors, and microglia.
• Immature oligodendrocyte: Sometimes referred to as premyelinating oligodendrocytes, these cells extend "pioneer processes" which contact axons and anchor premyelinating oligodendrocytes to neurons such that they are poised to commence myelinogenesis in response to axonal signals.
• GPR17 was first clone form and is highly expressed in certain precursors of oligodendrocytes in the nerve tissue of the central nervous system (CNS); it is overexpress in CNS tissues experiencing demyelination injuries; within 48 hours of the latter types of injuries, GPR17 expression is induced in dying neurons within and on the borders of injury, in infiltrating microglia and macrophages, and in activated oligodendrocyte precursor cells.
• These investigations have unveiled the involvement of osteocalcin with GPR37 to regulate processes such as oligodendrocyte differentiation, myelination, myelin production, and remyelination following demyelinating injuries.
• Butyrophilin has been presented as a potential antigen which may be similar enough to myelin oligodendrocyte glycoprotein (MOG) to spur the immune system to attack myelin in a process known as molecular or epitopic mimicry.
• The three major myelin-associated inhibitory factors are Nogo, oligodendrocyte myelin glycoprotein, and myelin-associated glycoprotein which all share this trimolecular receptor complex.
• NG2-positive cells include oligodendrocyte progenitor cells (OPCs) and other progenitor cell populations, such as chondroblasts, myoblasts, and pericytes, as well as several different tumors including glioblastoma multiforme and melanoma.
• Mice genetically engineered to lack the Hes3 gene exhibit differences in the amount of myelin basic protein (a protein expressed on myelinating oligodendrocytes), relative to normal mice; Hes3-lacking mice also exhibit a different regulation of this protein after oligodendrocyte damage induced by the chemical cuprizone.
• Serum anti-myelin oligodendrocyte glycoprotein antibodies are present in up to half of patients with an acquired demyelinating syndrome and have been described in association with a range of phenotypic presentations, including acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, and neuromyelitis optica.
• Today, Frequency's lead program is for remyelination in multiple sclerosis (MS) with a focus on developing a therapeutic that activates oligodendrocyte progenitor cells in the central nervous system to generate new oligodendrocytes and regenerate myelin, potentially repairing damage caused by MS.
• Accordingly, they probed the roles of Olig1 and Olig2 transcription factors in astroglial specification and found that just as Olig1/2 promote motor neuron specification and suppress interneuron specification in the neurogenic phase, Olig1/2 promote oligodendrocyte specification and suppress astroglial specification in the later phase.
• Dermal fibroblasts donated by the patients were also studied to reveal that iron toxicity is primarily responsible for oligodendrocyte death in early-onset PMD, and that treatment with deferiprone could rescue myelination in vitro and in mice.

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