Synonymer & Information om | Engelska ordet OVEREXPRESSION

Exempel på hur man kan använda OVEREXPRESSION i en mening

• Scleraxis expression will be seen throughout the entire sclerotome (rather than just the sclerotome directly anterior and posterior to the myotome) with an overexpression of FGF8, demonstrating that all sclerotome cells are capable of expressing scleraxis in response to FGF signaling.
• Ets1 overexpression in stratified squamous epithelial cells causes pro-oncogenic changes, such as suspension of terminal differentiation, high secretion of matrix metalloproteases (Mmps), epidermal growth factor ligands, and inflammatory mediators.
• Although the precise cause of Uhl's anomaly is unknown, there have been reports of primary nondevelopment of myocytes, selective apoptosis, and cardiomyocyte overexpression of vascular endothelial growth factor.
• High-sugar and high-fat foods have been shown to increase the expression of ΔFosB, an addiction biomarker, in the D1-type medium spiny neurons of the nucleus accumbens; however, there is very little research on the synaptic plasticity from compulsive food consumption, a phenomenon which is known to be caused by ΔFosB overexpression.
• The disease is strongly correlated with the genetic translocation t(14;18), which results in juxtaposition of the bcl-2 proto-oncogene with the heavy chain JH locus, and thus in overexpression of bcl-2.
• An overexpression of RANKL can cause an overproduction and activation of osteoclasts, which break down bone.
• Somatic mutation, such as deletion of chromosome 9q, 9p, 11p, 17p, 13q, 14q and overexpression of RAS (oncogene) and epidermal growth factor receptor (EGFR).
• T-cadherin overexpression in ECs facilitates spontaneous cell migration, formation of stress fibers and change of the phenotype from quiescent to promigratory.
• Due to its cytoprotective effects, overexpression of SOD2 has been linked to increased invasiveness of tumor metastasis.
• Deletion of Grem1 in mice after birth increased bone formation and increased trabecular bone volume, whereas overexpression causes inhibition of bone formation and osteopenia.
• Further studies performed in mice have shown that overexpression of Ascl1 in Müller glia in conjunction with administration of a histone deacetylase inhibitor allowed for regeneration of retinal neurons from Müller glia.
• Murine models of HER2 overexpression in conjunction with PTPN1 knockout resulted in delayed tumor growth and with fewer observed metastases to the lung suggesting that PTPN1 may have an oncogenic role in breast cancer.
• Therefore, its overexpression is a common consequence of dysregulation of the p53-p21-Cdk axis in carcinogenesis.
• Inflammatory breast cancer is a high-grade aneuploid cancer, with mutations and overexpression of p53, high levels of E-cadherin and abnormal cadherin function.
• Both the overexpression of Met/HGFR, as well as its autocrine activation by co-expression of its hepatocyte growth factor ligand, have been implicated in oncogenesis.
• Additionally, silencing of GLS and overexpression of GLS2 genes cooperate in decreasing the proliferation and viability of glioblastoma cells.
• In vivo overexpression of S100A4 led to a significant increase in tumor growth and vascularization in a human melanoma xenograft M21 model.
• The dysregulation and overexpression of HIF1A by either hypoxia or genetic alternations have been heavily implicated in cancer biology, as well as a number of other pathophysiologies, specifically in areas of vascularization and angiogenesis, energy metabolism, cell survival, and tumor invasion.

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