Anagram & Information om | Engelska ordet PROTEASOMAL

Exempel på hur man kan använda PROTEASOMAL i en mening

• Vif interacts with APOBEC3G and triggers the ubiquitination and degradation of APOBEC3G via the proteasomal pathway.
• On the contrary, after DNA damage, ATM phosphorylates CK1δ, which can subsequently phosphorylate Mdm2 inducing its proteasomal degradation.
• To circumvent the anti-viral potential, influenza A virus dysregulates HDAC2 by inducing its degradation by proteasomal degradation.
• Of the ubiquitin-like proteins that have been identified, UBD is the only one of that conjugate to target proteins by a free diglycine motif at the C-terminus and directly guides noncovalently bound proteins to proteasomal degradation.
• HERC2 has recently been associated with regulating iron metabolism through ubiquitinating the F-box and leucine-rich repeat protein 5 (FBXL5) for proteasomal degradation.
• "Lamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10".
• Further work by Zoghbi, Orr and their teams demonstrated that the misfolding, aggregation, and proteasomal degradation of the protein product of this gene, Ataxin 1, played a role in the disorder.
• Nef and Vpu proteins can also direct CD4 co-receptor for lysosomal (Nef) or cytosolic proteasomal (Vpu) degradation, affecting the recognition of MHC II-bound peptides.
• A misfolded protein will be recognized and tightly taken care of by either refolding or ubiquitination and proteasomal degradation.
• For example, conjugation of JQ1 to phthalimide moieties such as that found in thalidomide recruits the E3 ubiquitin ligase cereblon (CRBN) to effect proteasomal degradation of BRD4.
• Attachment of Lys(63)-linked polyubiquitination chains induces proteasomal degradation of several α-arrestins, which is antagonized by the deubiquitinating enzymes (DUBs) Ubp2 and Ubp15.

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