Information om | Engelska ordet RYANODINE

Exempel på hur man kan använda RYANODINE i en mening

• An activation of smooth muscle cells through caffeine activates ryanodine receptors of the sarcoplasmic reticulum, whereas an activation through high levels of extracellular potassium depolarizes the membrane (due to the change of the reversal potential for potassium towards more positive values) and would then activate voltage-gated calcium-ion channels leading to high levels of intracellular calcium ions.
• Their homeothermy may also rely on SERCA2 and ryanodine receptor 2 protein expression, which may have a cardioprotective effect.
• At nanomolar concentrations, ryanodine locks the receptor in a half-open state, whereas it fully closes them at micromolar concentration.
• These calcium waves are much more likely to occur when cardiac muscle cells are stimulated by catecholamines such as adrenaline, which increase the concentration of calcium within the sarcoplasmic reticulum and sensitise the ryanodine receptors.
• These DHPRs are located directly opposite to the ryanodine receptors, located on the sarcoplasmic reticulum and activation, by the action potential causes the DHPRs to change shape.
• These include the sodium, potassium, calcium, ryanodine receptor, HCN, CNG, CatSper, and TRP channels.
• These cardiac dyads also known as junctional membrane complexes or calcium release units are thought to play a key role in calcium induced calcium release by approximating L-type calcium channels on the plasma membrane and ryanodine receptor type 2 on the sarcoplasmic reticulum.
• One study showed that the death/C-terminal domain of ankyrin-B determines both the subcellular localization as well as activity in restoring normal inositol trisphosphate receptor and ryanodine receptor localization and cardiomyocyte contractility.
• Secondly, the nitroxyl group from CXL 1020 interacts with ryanodine receptors (RyR), specifically RyR2, which is the predominant form found in cardiac tissue.
• Ryanoids include natural chemicals which are closely related to ryanodine, such as ryanodol and 9,21-didehydroryanodol, and also chemically distinct synthetic compounds such as chlorantraniliprole (Rynaxypyr), flubendiamide, cyantraniliprole, cyclaniliprole, and tetraniliprole (Tetrino), which are called diamide insecticides.
• Her laboratory uses calcium imaging combined with electrophysiological, biochemical, and molecular techniques to study the classes of calcium release channels known to exist inside virtually all cells: the inositol trisphosphate receptor-gated channel, the ryanodine receptor, and polycystin 2.
• The species is significant partly because the ryanoid insecticides are derived from, and have the same mode of action as, the alkaloid ryanodine, which was originally extracted from this South American plant, which is also used as a piscicide.
• A triad protein complex plays a role converting electrical excitation into calcium release, and it is composed of two calcium channels, the ryanodine receptor (RYR1), and the dihydropyridine receptor (DHPR).

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