Information om | Engelska ordet SINGLE-CHAIN

Exempel på hur man kan använda SINGLE-CHAIN i en mening

• GH is a 191-amino acid, single-chain polypeptide that is synthesized, stored and secreted by somatotropic cells within the lateral wings of the anterior pituitary gland.
• Each thurible consists of a censer section, chains (typically three or four, although single-chain thuribles also exist), a metal ring around the chains (used to lock the lid of the censer section in place), and usually (although not always) a removable metal crucible in which the burning charcoals are placed.
• To enhance its stability, single-chain monellin proteins were created in which the two natural chains are joined via a Gly-Phe dipeptide linker.
• This work prompted CD3ζ intracellular domains to be added to chimeric receptors with antibody-like extracellular domains, commonly single-chain fraction variable (scFv) domains, as well as proteins such as CD4, subsequently termed first generation CARs.
• In the single-chain system, the chain runs from the top of a chainring attached to the cranks to the top of a sprocket attached to the rear wheel hub with a freewheel, as with most bicycle chain drives.
• All selectins are single-chain transmembrane glycoproteins that share similar properties to C-type lectins due to a related amino terminus and calcium-dependent binding.
• Examples include chimeric and humanized minretumomab, as well as a fusion protein of a minretumomab single-chain variable fragment and the enzyme beta-lactamase.
• In 1988, the single-chain variable fragment (scFv) was invented by the Huston team to minimize the refolding problems, which contains the incorrect domain pairing or aggregation of two-chain species.
• It is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing.
• BiTE molecules are fusion proteins consisting of two single-chain variable fragments (scFvs) of different antibodies, or amino acid sequences from four different genes, on a single peptide chain of about 55 kilodaltons.
• Because naturally occurring antibodies are optimised to be secreted from the cell, cytosolic intrabodies require special alterations, including the use of single-chain antibodies (scFvs), modification of immunoglobulin VL domains for hyperstability, selection of antibodies resistant to the more reducing cytosolic environment, or expression as a fusion protein with maltose binding protein or other stable intracellular proteins.
• Interlocking chain actuators have the advantages over single-chain actuators of improved resistance to buckling and that the actuating member does not require lateral restraint at its leading end in order to resist a modicum of transverse loads on any edge of the member.
• It is a fusion protein consisting of two single-chain variable fragments (scFvs) of different antibodies on a single peptide chain of about 55 kilodaltons.
• Brolucizumab sold under trade name Beovu among others, is a humanized single-chain antibody fragment for the treatment of neovascular (wet) age-related macular degeneration (AMD).
• In ultrasonics, Mason provided the first demonstration of single-chain viscoelasticity in which the elasticity is due to the individual molecular chains themselves rather than their entanglement.
• Decarboxylative condensations for a single-chain elongation are facilitated by β-ketosynthase (KS), acyl transferase (AT), and acyl carrier protein (ACP).

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