Synonymer & Information om | Engelska ordet THROMBIN

Exempel på hur man kan använda THROMBIN i en mening

• These platelets have thrombin receptors on their surfaces that bind serum thrombin molecules, which in turn convert soluble fibrinogen in the serum into fibrin at the wound site.
• It is proteolytically cleaved during the clotting process by the prothrombinase enzyme complex to form thrombin.
• Platelet aggregation is normal with ristocetin, but impaired with other agonists such as ADP, thrombin, collagen, or epinephrine.
• Once bound to TF, FVII is activated to FVIIa by different proteases, among which are thrombin (factor IIa), factor Xa, IXa, XIIa, and the FVIIa-TF complex itself.
• The basic purpose of these tests is to determine the cause of prolongation of Prothrombin Time (PT), Partial Thromboplastin Time, or sometimes of thrombin time (TT).
• Additionally, protein S has a peptide between the Gla domain and the EGF-like domain, that is cleaved by thrombin.
• The protein C zymogen is activated when it binds to thrombin, another protein heavily involved in coagulation, and protein C's activation is greatly promoted by the presence of thrombomodulin and endothelial protein C receptors (EPCRs).
• It acts by cleaving prothrombin in two places (an Arg-Thr and then an Arg-Ile bond), which yields the active thrombin.
• The zymogen factor is activated into factor XIa by factor XIIa (FXIIa), thrombin, and FXIa itself; due to its activation by FXIIa, FXI is a member of the "contact pathway" (which includes HMWK, prekallikrein, factor XII, factor XI, and factor IX).
• The C-terminal domain makes numerous electrostatic interactions with an anion-binding exosite of thrombin, while the last five residues are in a helical loop that forms many hydrophobic contacts.
• In the presence of calcium and phospholipids, these factors convert prothrombin into thrombin, leading to fibrin clot formation.
• Its role in the blood clotting is the initiation of thrombin formation from the zymogen prothrombin.
• The prothrombinase complex catalyzes the conversion of prothrombin (factor II), an inactive zymogen, to thrombin (factor IIa), an active serine protease.
• In normal conditions, fibrinogen is converted to fibrin when it is cleaved by the enzyme thrombin in the blood.
•  schlegeli venom are phospholipase A2 related to the production of edema, tissue damage and myotoxicity, metalloproteases with dermonecrosis, L-amino acid oxidases with tissue damage, serine proteases with tissue damage and hemorrhagic diathesis, lectin type C with tissue damage and hemorrhagic diathesis, disintegrins with detachment of cells from their extracellular matrix leading to blisters and platelet function impairment, bradykinin-potentiating peptides with hypotension, enzymes that degrade fibrinogen, plasminogen activators, prothrombin activators, factor V activators, factor X activators, and anticoagulant activities (including inhibitors of prothrombinase complex formation, inhibitors of thrombin, phospholipases, and protein C activators).
• When megakaryocytes and endothelial cells are activated by agonists such as thrombin, P-selectin is rapidly translocated to the plasma membrane from granules.
• Thrombomodulin functions as a cofactor in the thrombin-induced activation of protein C in the anticoagulant pathway by forming a 1:1 stoichiometric complex with thrombin.
• Dalteparin acts by potentiating the activity of antithrombin III, inhibiting formation of both Factor Xa and thrombin.
• Thromboplastin acts on and accelerates the activity of Factor Xa, also known as thrombokinase, aiding blood coagulation through catalyzing the conversion of prothrombin to thrombin.
• Danaparoid sodium (Orgaran) is an anticoagulant with an antithrombotic action due to inhibition of thrombin generation (TGI) by two mechanisms: indirect inactivation of Factor Xa via AT and direct inhibition of thrombin activation of Factor IX (an important feedback loop for thrombin generation).

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