Information om | Engelska ordet TMPRSS2

Exempel på hur man kan använda TMPRSS2 i en mening

• SARS-CoV-2 uses the SARS-CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming.
• In low cholesterol ACE2 traffics the virus to TMPRSS2 which also cleaves and allows viral entry but through a putative surface mechanism that is much less efficient.
• They found that the protease TMPRSS2 is split by the virus' spike protein to enter the cell and that the TMPRSS2-inhibitors Camostat and, in a second report by other researchers on 18 March, Nafamostat may be potential treatments as they reduced the probability of the virus entering cells in vitro.
• Cleavage of the SARS-CoV-2 S2 spike protein required for viral entry into cells can be accomplished by proteases TMPRSS2 located on the cell membrane, or by cathepsins (primarily cathepsin L) in endolysosomes.

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