Information om | Engelska ordet TOPHI

The specific diseases and conditions where it is used include gouty arthritis, skin tophi, kidney stones, idiopathic gout; uric acid lithiasis; acute uric acid nephropathy; neoplastic disease and myeloproliferative disease with high cell turnover rates, in which high urate levels occur either spontaneously, or after cytotoxic therapy; certain enzyme disorders which lead to overproduction of urate, for example: hypoxanthine-guanine phosphoribosyltransferase, including Lesch–Nyhan syndrome; glucose 6-phosphatase including glycogen storage disease; phosphoribosyl pyrophosphate synthetase, phosphoribosyl pyrophosphate amidotransferase; adenine phosphoribosyltransferase.
A tophus (Latin: "stone", : tophi) is a deposit of monosodium urate crystals, in people with longstanding high levels of uric acid (urate) in the blood, a condition known as hyperuricemia.
In 1679, van Leeuwenhoek used a microscopes to assess tophaceous material and found that gouty tophi consist of aggregates of needle-shaped crystals, and not globules of chalk as was previously believed.
Gouty arthritis, commonly referred to as gout, is another form of inflammatory arthritis that can lead to hand deformities due to deposition of monosodium urate crystals in the joints and other tissues, forming nodular masses known as tophi.

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