Synonymer & Information om | Engelska ordet POLYKETIDE

Exempel på hur man kan använda POLYKETIDE i en mening

• Priming beta-ketosynthase in chemistry, a domain of polyketide synthases with a thiol group on a cysteine side-chain.
• Further studies in 1903 by Collie on the triketone polyketide intermediate noted the condensation occurring amongst compounds with multiple keten groups coining the term polyketides.
• The enzyme chalcone synthase, a type III polyketide synthase, is responsible for the biosynthesis of these compounds.
• The enzyme MCAT together with an acyl carrier protein (ACP), and a polyketide synthase (PKS) and chain-length factor heterodimer, constitutes the minimal PKS of type II polyketides.
• 4'-Phosphopantetheine is a prosthetic group of several acyl carrier proteins including the acyl carrier proteins (ACP) of fatty acid synthases, ACPs of polyketide synthases, the peptidyl carrier proteins (PCP), as well as aryl carrier proteins (ArCP) of nonribosomal peptide synthetases (NRPS).
• Cyanidin can be synthesized in berry plants through the shikimate pathway and polyketide synthase (PKS) III.
• Tautomycin is closely related to another anhydride containing polyketide PP inhibitor called tautomycetin which, in addition to being useful as a lead for cancer drug discovery, also is a very potent immunosuppressor.
• Birch and others identified citrinin as a polyketide and investigated its biosynthesis using radioisotopes.
• Condensation reaction catalysed by the polyketide synthase Pks13 between the α-branch and the meromycolate chain before a final reduction by the enzyme corynebacterineae mycolate reductase A (CmrA) to generate the mycolic acid; and.
• tuberculosis mutations in the rpoB gene can significantly upregulate polyketide synthase, potentially indicating increased production of phthiocerol dimycocerosate, a lipid produced by M.
• The biosynthesis of neocarzinostatin takes place through a convergence of the activities of a gene cluster, which includes two separate iterative type I polyketide synthase (PKS) and deoxy sugar biosynthetic pathways.
• Three plasmid-encoded polyketide synthase (PKS) enzymes are responsible for its production: MLSA 1 and MLSA 2 which generate the core, and MLSB is responsible for the synthesis of the polyketide chain.
• Phosphopantetheine, also known as 4'-phosphopantetheine, is a prosthetic group of several acyl carrier proteins including the acyl carrier proteins (ACP) of fatty acid synthases, ACPs of polyketide synthases, the peptidyl carrier proteins (PCP), as well as aryl carrier proteins (ArCP) of nonribosomal peptide synthetases (NRPS).
• lacrymans genome encodes six annotated polyketide synthases (PKS1-PKS6), 15 nonribosomal peptide synthetases (NPS1-NPS4, NPS7, NPS13-NPS15, NPS17, and NPS18), and two hybrids thereof (NPS6, NPS8, and NPS16).
• Brevetoxins share the common backbone structure of polyketides, but there are several methyl and oxygen groups that are not typical in traditional polyketide biosynthesis.
• Polyketide synthases (PKSs) are a family of multi-domain enzymes or enzyme complexes that produce polyketides, a large class of secondary metabolites, in bacteria, fungi, plants, and a few animal lineages.
• Chalcone synthase or naringenin-chalcone synthase (CHS) is an enzyme ubiquitous to higher plants and belongs to a family of polyketide synthase enzymes (PKS) known as type III PKS.
• Biosynthesis of radicicol has been best studied in Pochonia chlamydosporia, in which the majority of the core structure is produced in vivo through iterative type I polyketide synthases.
• Beta-ketoacyl-ACP synthase is found as a component of a number of enzymatic systems, including fatty acid synthetase (FAS); the multi-functional 6-methysalicylic acid synthase (MSAS) from Penicillium patulum, which is involved in the biosynthesis of a polyketide antibiotic; polyketide antibiotic synthase enzyme systems; Emericella nidulans multifunctional protein Wa, which is involved in the biosynthesis of conidial green pigment; Rhizobium nodulation protein nodE, which probably acts as a beta-ketoacyl synthase in the synthesis of the nodulation Nod factor fatty acyl chain; and yeast mitochondrial protein CEM1.
• The anthracycline skeleton of doxorubicin (DXR) is produced by a Type II polyketide synthase (PKS) in streptomyces peucetius.

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